Regarding safety and AEs, in a real-life observational study reported by Peet et al. and carried out in autoinflammatory patients treated with different biologics (IL-1i, IL-6 inhibitors, TNF-alpha inhibitors), side effects after vaccination against COVID-19 were reported after 71 of 138 (51.4%) administrations and were consistent with a flare of the underlying disease only in 26 of 138 (18.8%). The gene discussed is TNF; the disease is COVID-19.