Based on the results of the current study, SNPs of ADH7 rs3737482T>C and ADH7 rs1154460G>A are associated with the risk of the development of head and neck squamous cell carcinoma in Koreans and they could be potentially useful molecular biological markers for identifying individuals at high risk of developing HNSCC. This evidence concerns the gene ADH7 and head and neck squamous cell carcinoma.