CD40LG and septic shock: The history of intensive care medicine is characterized by several hotly debated issues, including the colloid-crystalloids controversy (actually recently replaced by discussions about the best crystalloid solution available), the use of steroids, the appropriate levels of oxygen delivery in critically ill patients, the selective decontamination of the digestive tract, etc. The very same considerations apply to the use of IvIg in septic shock patients and especially for those preparations enriched with supra-normal concentrations of IgM and IgA (eIg).