SHANK3 and autism: In an interesting study, Yan et al. reported reduced levels of the HDACs downstream target genes encoding the N-methyl-D-aspartate (NMDA) receptor subunits, glutamate ionotropic receptor NMDA type subunit 2A (GRIN2A) and glutamate ionotropic receptor NMDA type subunit 2 B (GRIN2 B) in the prefrontal cortex of an autism mouse model with a deficient Shank3 gene [192].