In contrast to our previous results showing that EGFRAP does not affect the proliferation of RasV12 in wing discs [12], here we find that elimination of either PVRAP or by slightly, but significantly, increases the number of RasV12 cells undergoing mitosis, suggesting that as is the case for the mammalian tensins, the different Drosophila tensins may regulate the behavior of tumor cells in a tensin-type-specific manner. This evidence concerns the gene TNS1 and neoplasm.