RHBDD3 and infectious disease: Furthermore, S100A6 is involved in the response to the viral infection causing porcine reproductive and respiratory syndrome (PRRS), one of the most economically significant swine infectious diseases [22,23]; PPGRP-S has a role in the immunity against intestinal microorganisms [24]; RHBDD3 suppresses, in mice, the production of IL6, preventing the development of autoimmune diseases [25]; and PLA2G3 affects the maturation and function of mast cells, key players in the inflammatory response [26].