Additionally, tumors bearing MGMT methylation had a significant trend toward lymph node metastasis (p = 0.001), lymph invasion (p = 0.005), venous invasion (p = 0.004), perineural invasion (p ≤ 0.001), distant metastasis (p ≤ 0.001) and relapse (p = 0.008). Here, MGMT is linked to metastatic malignant neoplasm in the lymph nodes.