Specifically, loss-of-function mutations in the filaggrin (FLG) gene, including the rs558269137 (2282del4) and rs61816761 (R501X) [6] Single-Nucleotide Polymorphisms (SNPs), which facilitates the formation of the cornified envelope, have been consistently associated with an increased risk for AD in various ethnic populations, due to their implication in the reduced granular layer [7]. This evidence concerns the gene FLG and Alzheimer disease.