Similarly, the synthesis of evidence from three studies evaluating the TLR2 rs4696480 SNP in 741 participants failed to establish a significant association with the risk of developing AD (OR (95% CI): 0.81 (0.62–1.06); I2 = 40.2%) (Figure 2; Supplementary Table S1). This evidence concerns the gene TLR2 and Alzheimer disease.