Despite the abundance of statistically significant associations between FLG variants and increased AD risk in both Europeans and Asians, several variants, including FLG rs61816761 (7 studies; n = 3085), FLG rs146466242 (5 studies; n = 1930), FLG rs772851618 (5 studies; n = 1857) and FLG rs11584340 (2 studies; n = 855), failed to provide significant signals (OR (95% CI): 0.45 (0.11–1.74); I2 = 0.0%; OR (95% CI): 0.54 (0.21–1.38); I2 = 1.7%; OR (95% CI): 2.39 (0.54–10.53); I2 = 0.0%; OR (95% CI): 0.80 (0.44–1.47); I2 = 86.5%) (Figure 3; Supplementary Table S2). The gene discussed is FLG; the disease is Alzheimer disease.