IL18 and Alzheimer disease: Despite the expanding list of risk loci identified through genome-wide scans in AD, our REM shed light upon new risk loci mapped to the IL18 and TGFB1 genes in Europeans (Figure 2), while the contribution of IL12RB1 and MIF loci in AD predisposition in Asians was additionally characterized through our analysis, revealing results not previously reported by genome-wide scans (Figure 3).