Nevertheless, data synthesis from four studies (n = 930) regarding the SPINK5 rs2303064 SNP showed no evidence for an association with AD predisposition in the Asian population (OR (95% CI): 0.97 (0.79–1.19); I2 = 0.0%) (Figure 3; Supplementary Table S2). This evidence concerns the gene SPINK5 and Alzheimer disease.