A differentially expressed gene analysis of CRC stages found 11 genes (NEK4, RNF34, HIST3H2BB, NUDT6, LRCh4, GLB1L, HIST2H4A, TMEM79, AMIGO2, C20orf135, and SPSB3) that change their expression depending on the stage [50]. The gene discussed is H2BC26; the disease is colorectal carcinoma.