WHO5 does not alter the classification of APL from WHO4R; however, it replaces the specific entities of “AML with t(9;11) (p21.3;q23.3)/MLLT3::KMT2A” and “AML with inv(3) (q21.3q26.2) or t(3;3) (q21.3;q26.2)/GATA2; MECOM(EVI1)” with the more generic driver-translocated groups denoted in the ICC [2]. The gene discussed is MECOM; the disease is acute myeloid leukemia.