RUNX1 and intrahepatic cholangiocarcinoma: The list of somatically mutated genes is largely shared between the systems and includes ASXL1, BCOR, EZH2, SF3B1, SRSF2, STAG2, U2AF1, and ZRSR2. As noted above in the section on the RUNX1 mutation, this is also considered myelodysplasia-related in the ICC but not in WHO5 [2,3,4].