Among this group, NUP98 rearrangements are highlighted as similar to rearrangements involving RARA, KMT2A, and MECOM; ICC recognizes distinct fusion partners and a generic group of “AML with NUP98 and other partners”, while WHO5 only recognizes the generic group of “AML with NUP98 rearrangement.” [2,3,4]. The gene discussed is MECOM; the disease is acute myeloid leukemia.