According to the results of the present study, infertile patients with this genetic variant in homozygous and compound heterozygous L138ins variant with another CF-causing mutation or 5T allele of the CFTR gene) have congenital aplasia of the vas deferens (obstructive azoospermia) as a result of CF or CBAVD syndrome. This evidence concerns the gene CFTR and Infertility.