Several loci on specific chromosomes have been studied and at least six disease loci of ET identified: (ETM1 (3q13, OMIM 190300), ETM2 (2p24.1, OMIM 602134), ETM3 (6p23 OMIM 611456), ETM4 (16p11.2 FUS gene OMIM 614782), ETM5 (11q14.1 TENM4 gene OMIM 610084), and ETM6 (1q21.2 NOTCH2NLC gene OMIM 618866). This evidence concerns the gene TENM4 and essential thrombocythemia.