MAPK1 and neuroblastoma: Downregulation of miR-335 causes upregulation of transforming growth factor-β (TGF-β) and its pathway members, namely Rho-associated coiled-coil containing protein 1 (ROCK1), mitogen-activated protein kinase 1 (MAPK1), and leucine-rich α-2 glycoprotein (LRG1), which leads to significant invasion and migratory potential in neuroblastoma cells [93].