Previous reports of the pathogenic variant c.7354C>T in RYR1 described a variable pattern of dysmorphic features and muscle biopsy (ClinVar RCV000056226.1) that ranged from MH with CCD to MH with cleft palate, increased creatine kinase, a strongly positive in vitro muscle contracture test, and normal muscle histology [15,16]. This evidence concerns the gene RYR1 and cleft palate.