Genetic predisposition was detected in only 7–10% of rhabdomyosarcoma patients [20]; in the present case, mutations in known cancer susceptibility genes could be excluded, but notably, a missense VUS was detected in ASPSCR1, and such variants have been associated with glioma and leukemia in pediatric patients [20]. The gene discussed is ASPSCR1; the disease is rhabdomyosarcoma.