The alveolar rhabdomyosarcoma histopathological and genetic variant exhibits frequent metastasis, worse prognosis, and the acquisition of somatic balanced chromosomal translocations with novel fusion genes (paired-box transcription factor 3 (PAX3) or 7 (PAX7) and forkhead box protein O1 (FOXO1)) [1,2]. Here, FOXO1 is linked to rhabdomyosarcoma.