The carriers of the rarest COMT rs4818-rs4680 haplotype (GA) had the highest scores on G1 item (somatic concern), while GG haplotype had the lowest scores on G2 (anxiety) and G6 (depression) items, compared to other haplotypes in male subjects (Table 3, Figure 2b–d and Figure 3b–d). Here, COMT is linked to depressive disorder.