While it is unknown if COMT gene has any role in the evolutionary paradox in schizophrenia, we speculate that the relation between COMT polymorphisms and haplotype combinations (associated with higher enzymatic activity), with lower intensity of some symptoms in schizophrenia, may suggest distinct impact of the COMT genes on schizophrenia onset and schizophrenia severity. The gene discussed is COMT; the disease is schizophrenia.