As a result of linear regression analysis conducted in the DeprVUR sample controlling for sex, ethnicity, and age, we observed significant effects of the PCLO rs2715157 A-allele (β = 0.67, p = 0.03) and the IL18 rs187238 C-allele (β = 0.73, p = 0.03) on BDI-measured depression. This evidence concerns the gene IL18 and depressive disorder.