Roman-Gomez et al. hypothesized that destabilization of repetitive sequences (i.e., L1 hypomethylation) could be one of such mechanisms employed by BCR-ABL to generate genomic instability in the malignant cell, suggesting that repetitive DNA hypomethylation is closely associated with CML progression [26]. Here, ABL1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.