Neurodegeneration is mediated by inflammatory and neurotoxic mediators such as chemokine (C-C motif) ligand 2 (CCL2), CCL5, tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) etc. The increased level of these mediators including CCL2 lead to neurodegeneration and neuronal death in neurodegenerative diseases [26,40]. The gene discussed is TNF; the disease is neurodegenerative disease.