Afirma XA provides information about inherited syndromes with increased likelihood of thyroid malignancy, such as RET (multiple endocrine neoplasia 2; MEN2), PTEN (PTEN hamartoma tumor syndrome; Cowden syndrome), APC (APC-associated polyposis; familial adenomatous polyposis) and DICER1 (DICER1 syndrome). The gene discussed is APC; the disease is thyroiditis.