Even though it is described that tissues targeted by insulin release miRNAs into the extracellular space [23,24], and these are involved in the onset of microvascular complications of T2D [15,19,25], there are only few studies investigating the circulating miRNAs signature of the initial stages of disease, when the alterations in glucose metabolism are still mild and clinically asymptomatic [26,27]. Here, INS is linked to type 2 diabetes mellitus.