CRB1 and retinitis pigmentosa 1: In five patients with biallelic Crumbs cell polarity complex component 1 (CRB1)-associated RP, loss of photoreceptors may be an early finding in asymptomatic patients [66], supporting that AO imaging may be more sensitive than conventional techniques, such as SD-OCT, in detecting subtle structural damage and diagnosing early-stage CRB1-associated retinopathy.