RPE65 and Leber congenital amaurosis: In a longitudinal study over 21 to 29 months on 3 cases of RPE65-associated Leber congenital amaurosis (LCA), Kalitzeos et al. found that while there were no visualized changes in confocal AOSLO, non-confocal split-detection showed inner segment enlargement along with a reduction in foveal cone density over time [100].