RPS6KB1 and diabetes mellitus: To verify this diabetes-induced p70S6K1 over-phosphorylation, a retrospective study consisting in IHC staining of both phospho-p70S6K1 and total p70S6K1 protein expression was performed using invasive ductal carcinoma (IDC) FFPE tissues extracted from 16 postmenopausal T2DM and 16 non-diabetic patients enrolled in 2016–2017 at the Oncology Division, King Abdullah Medical City, Riyadh, Saudi Arabia.