IRS2 and breast cancer: Additional genetic polymorphisms-related studies reported more diabetes-related risk SNPs (i.e., solute carrier family 30 member 8 SLC30A8-rs4876369 and insulin receptor substrate 2 IRS2-rs2241745) associated with first primary invasive breast cancer risk in 817 Caucasian women while other SNPs (i.e., cyclin-dependent kinase inhibitor CDKN2A/CDKN2B-rs3218020, Cdk5 regulatory subunit-associated protein 1-like 1 CDKAL1-rs981042, transcription factor 2/Hepatocyte nuclear factor-1-beta TCF2/HNF1B-rs3094508) were strongly associated with breast cancer-specific mortality [54].