Another study of 102 cases of T2DM patients diagnosed with breast cancer and 106 non-diabetic counterparts reported higher proportions of local recurrence, lymph node metastasis, and distant metastasis and a significant increase in IGF-1R and Ki-67 in the T2DM breast cancer group than in the non-diabetic breast cancer group [200]. This evidence concerns the gene MKI67 and type 2 diabetes mellitus.