The ribosomal protein (p70) S6 Kinase 1 (p70S6K1) is the downstream effector of lipid kinase PI3K/Akt/mTOR complex 1 (PAM), one of the most important and active pathways in breast cancer including TNBC and in metabolic alterations such as T2DM [222,223]. This evidence concerns the gene RPS6KB1 and type 2 diabetes mellitus.