A clinical study reported the influence of pathogenic factors of T2DM on the activation of the PAM pathway, resulting in p70S6K1 phosphorylation detected in peripheral blood mononuclear cells (PBMCs) collected from postmenopausal healthy women, T2DM women, women diagnosed with endometrial and breast cancer, and from T2DM postmenopausal women diagnosed with endometrial and breast cancer [226]. This evidence concerns the gene RPS6KB1 and breast carcinoma.