Our current data revealed the over-phosphorylation of the ribosomal p70S6K1 intensely detected in IDC tissues of diabetic women compared to those observed in their non-diabetic counterparts’ IDC tissues, suggesting phospho-p70S6K1 as a promising therapeutic target against invasive breast cancer diagnosed in T2DM patients. This evidence concerns the gene RPS6KB1 and type 2 diabetes mellitus.