MKI67 and infection: The American Society for Colposcopy and Cervical Pathology (ASCCP) recommended endocervical curettage for patients with high-grade cytology, human papillomavirus 16/18 infection, positive p16/Ki67 dual staining, for those previously treated for cervical pre-cancer or considering an observation of CIN2 and when the squamocolumnar junction is not fully visualized at colposcopy [22].