Gupta et al. studied 30 patients with HRS type 1 (now HRS-AKI) and found that norepinephrine plus albumin administered for 14 days was associated with a 73% response rate (as evidenced by a decrease in SCr to <1.5 mg/dL, and increase in creatinine clearance, urine output, MAP, and serum sodium) [75]. The gene discussed is ALB; the disease is acute kidney injury.