The four DMRs that passed the Bonferroni correction (Bonferroni-adjusted p-value = 3.40 × 10−4) were located in D-Loop, mt-ND4, mt-RNR2, and mt-TT/mt-TP, and three of them displayed hypomethylation in the plasma cfDNA of AD patients (Figure 3C). This evidence concerns the gene MT-ND4 and Alzheimer disease.