LEP and obesity due to melanocortin 4 receptor deficiency: Four SNPs related to lipid metabolism and the risk for the MetS were selected and analyzed: APOA5 Q139X (rs121917821), CETP (Taq1B) (cholesterol ester transfer protein Taq1B) (rs708272), LPL Hinf I (rs328), PON1 (human paraoxonase 1) 192Arg/Gln (rs662), and two SNPs associated with obesity: LEP (leptin) 25CAG (rs104894023) and ADIPOQ (adiponectin) 45T>G (rs2241766) [131].