LDLR and familial hyperaldosteronism: Homozygous mutations in the LDLR gene cause a very severe form of FH, an autosomal recessive disease (HoFH), and are associated with plasma LDL-C levels approximately 6–10 times higher (600–1200 mg/dL) detected from birth; they are also associated with increased risks for premature ASCVD and death [17,18].