The ADRB2 Gln27Glu (rs1042714), AGT Thr174Met (rs4762), and AGTR1 A1166C (rs5186) polymorphisms were not associated with hyperinsulinism and insulin resistance in the Kazakh population, but carriers of the G allele of LPL Ser447Ter (rs328) were associated with a lower risk of hyperinsulinism (p = 0.037) [130]. This evidence concerns the gene ADRB2 and Insulin resistance.