Common LPL gene mutations (Asp9Asn, Asn291Ser, Trp86Arg, Gly188Glu, Pro207Leu, Asp250Asn) associated with type I hyperlipoproteinemia have been detected in approximately 20% of patients with hypertriglyceridemia [48]. This evidence concerns the gene LPL and familial lipoprotein lipase deficiency.