Considering the potential significance of CXCL6 overexpression and its CXCR2 receptor in the tumor microenvironment (TME), with implications for HCC development and progression, we conducted staining procedures on clinical samples derived from our hospital’s hepatocellular carcinoma (HCC) cohort (n = 50). This evidence concerns the gene CXCL6 and hepatocellular carcinoma.