The folate-conjugated micelle has similar cytotoxicity to the PEGylated phytozoa casein nanoparticle. Both nanoparticles have significantly higher cytotoxicity than free drugs. Significant reduction of body weight loss, tumor weight and volume, suppression of aromatase, NF-dB, VEGF, CD-1, and elevation of Caspase-3 demonstrated by both nanoparticles in vivo. Here, CYP19A1 is linked to neoplasm.