Mechanistically, CASZ1 directly promotes transcription of neural differentiation markers NGFR, TH and upregulates cell adhesion genes protocadherin 1 (PCDH1), CD9 molecule (CD9) and intercellular adhesion molecule 2 (ICAM2), which have suppressive effects on NB cell migration [14,74,75]. Here, PCDH1 is linked to neuroblastoma.