Interestingly, in cancers, CASZ1 was found to function as pro- and anti-oncogenic, which depends on cell/tumor types: neuroblastoma (NB) is the earliest and mostly used tumor model for CASZ1 studies, in which CASZ1 shows suppressive effects on NB cell proliferation and metastasis, and promotes cell differentiation [14]; however, in epithelial ovarian cancer, glioma and lung adenocarcinoma, CASZ1 is oncogenic and related to a worse prognosis [15,16,17]. The gene discussed is CASZ1; the disease is neoplasm.