CASZ1 and cancer: ITGAV can assemble into dimers with integrin subunit β1/3/5/6/8, interacting with ECM such as fibronectins and activating intracellular pathways for cancer cell invasiveness; it also promotes cell proliferation in breast cancer, although this has not been substantiated in LUAD, but might explain the oncogenic effect of CASZ1 on LUAD [15,84,85].