Clinical cases displayed CASZ1 mutations in congenital heart diseases, while GWAS (Genome-wide association studies) and EWAS (Epigenome-Wide Association Studies) discovered the association of CASZ1 single nucleotide polymorphisms (SNPs) or aberrant epigenetic status with chronic venous disease (CVD), hypertensive diseases, and all-cause mortality for cardiovascular disease populations [10,11,12,13]. This evidence concerns the gene CASZ1 and congenital heart disease.