Furthermore, through the abnormal regulation of phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt), which targets the mTOR pathway, this type of miRNA influences the development of neurological diseases; downregulation of has-miR-129-5p results in neuroinflammation and the development of neurodegenerative diseases, whereas upregulation results in protection from neural apoptosis [14,15,16]. This evidence concerns the gene AKT1 and neurodegenerative disease.