E2F1 and cancer: Several available reports have demonstrated that certain lncRNAs can trigger chemoresistance in diverse cancers, primarily by dysregulating apoptosis and promoting DNA repair processes [45] For instance, downregulation of ERIC (E2F1-Regulated Inhibitor of Cell death) lncRNA in osteosarcoma cells increases the rate of apoptosis among the etoposide treated cells, indicating ERIC enrollment in etoposide resistance [46].