Now, it seems that very few (or probably zero) cases present with just these alterations; usually amyloidosis is accompanied by multiple proteinopathies [5] (some people read this pathological picture as a series overlapping with other neurodegenerative pathologies), such as hyperphosphorylated tau protein, TDP-43, α-synuclein or the prion protein. Here, MAPT is linked to proteostasis deficiencies.