Corroborating this assertion, an altered PAX6 pathway in AD individuals [10] (similar to what happens in certain retinal dystrophies, where PAX2 is closely related to PAX6 [11]) was described and TREM2 (a microglial triggering receptor, also involved in amyloid phagocytosis) mutations are supposed to be involved in autism [12]. Here, TREM2 is linked to Alzheimer disease.