APOE and Alzheimer disease: Among the genetic risk factors for the development of AD are [6]: (i) presence of the ApoE ε4 allele [9], where the number of copies of ε4 influences the level of risk and is related to the age of presentation of the clinical disease [10]; and (ii) a first-degree family history of AD, which increases the probability of developing this neurodegeneration in the future by 2.9 to 6.1 times compared to subjects with no family history [11].