In particular, in a rat model of colorectal cancer, resveratrol has been shown to upregulate Muc-2 expression in colon tissue once administered for 30 weeks, together with a suppressive effect on several neoplastic markers (e.g., cyclooxygenase-2, ornithine decarboxylase), although the mechanism underlying the beneficial effects of resveratrol on Muc-2 content was not investigated [26]. The gene discussed is MUC2; the disease is colorectal cancer.