HIF1A and cancer: Since current treatment is influenced by factors such as cancer types and histological subtypes, we determined the prognostic relevance of BIRC5/FLT4/HIF1A at different stages of LUAD, and we found that BIRC5, FLT4, and HIF1A were higher in stages 2, 3, and 4 than in stage 1, where they were significantly lower.