However, recent reports have demonstrated that 1) the AH concentrations of TGF-β-2 are higher in patients with primary open angle glaucoma (POAG) but are lower in patients with pseudo exfoliation glaucoma (PXF), and 2) the AH concentrations of TGF-β-1 and TGF-β-3 are markedly increased in patients with PXF in comparison with other types of glaucoma [29,32,56,57], suggesting that the three TGF-β isoforms may be diversely involved in the pathological mechanisms of several types of glaucoma. Here, TGFB1 is linked to open-angle glaucoma.