However, as PDGFRA is not mutated in 100% of H3.3-G34R/V mutant gliomas, perhaps there are different ways that the mutant cells can become gliomas, similar to how PDGFRA reflects an oligodendroglial differentiated type of diffuse intrinsic pontine glioma (DIPG) in contrast to a mesenchymal type [88]. Here, PDGFRA is linked to central nervous system cancer.