ATRX and central nervous system cancer: Additionally, in one analysis, the only H3.3-G34R/V mutant glioma with both TP53-wt and ATRX-wt harbored a PDGFRA mutation [85] (although this mutant also harbored a TERT promoter mutation, which is not thought to be associated in the gliomagenesis of H3.3-G34R/V mutants).