In established RA, important genes involved in RA pathogenesis, which were found to be hypomethylated in the B-cells and distinguish patients from healthy individuals include: BARX2 encodes for a transcription factor, which influences cell processes involved in cell adhesion and migration, ASB1 mediates degradation of proteins including JAK2, involved in RA inflammation, ADAMTS17 a metalloprotease, MGMT a methyltransferase [68]. This evidence concerns the gene JAK2 and rheumatoid arthritis.