ACE and fibrosis: ARBs and neprilysin inhibitors (Valsartan and Sacubitril) reduced fibrosis, pulmonary pressures, vascular remodeling, as well as right-ventricle hypertrophy in a rat model [67], while both ARBs and ACE-Is have been shown to possess a modulating effect in idiopathic pulmonary fibrosis [23].