This hybrid nanovesicle comprises a cancer cell membrane (enhancing the ability of homologous targeting) and a CPP-bound MMP-9 sensitive peptide (R9-PVGLIG-EGGEGGEGG) that carries DTX, lipoic acid-modified Polypeptide (LC) and siRNA of PGAM1 (a key aerobic glycolytic enzyme in cancer metabolism) to treat lung cancer [137]. Here, MMP9 is linked to cancer.