Considering asthma, CRSwNP patients, with or without concomitant asthma, showed higher IL5RA expression than controls (10.3 ± 18.5 and 10.6 ± 8.26, respectively, p < 0.001), as well as both CRSwNP with AA and CRSwNP with NAA groups (10.2 ± 20.1 and 10.7 ± 18.1, respectively, p < 0.001). This evidence concerns the gene IL5RA and chronic rhinosinusitis with nasal polyps.