When the two meningioma cell lines were treated with CEP-1347 at concentrations up to 500 nM, a range of concentrations that do not significantly inhibit the growth of normal human fibroblasts (IMR90), IOMM-Lee cells were more sensitive to growth inhibition by CEP-1347 than HKBMM cells (Figure 1B), which supports the p53 status being predictive of the sensitivity of cells to CEP-1347. Here, TP53 is linked to meningioma.