HNF1A and maturity-onset diabetes of the young type 3: Mutations in the HNF1A gene are responsible for MODY3, characterized by severe pancreatic beta cell insulin secretory defects [26], although the clinical expression may vary considerably, and MODY3 subjects may present with a defect in insulin secretion, as well as the full spectrum of complications typical of diabetes, such as microvascular complications or those involving the kidneys [26,27,28].