Meanwhile, the HIF-dependent response of body tissues to hypoxia in CHD patients, suffering and not suffering from ICMP, was different (Figure 1B,C): in cardiomyopathy, HIF-1α deficiency was present, against the background of significantly more frequent HIF-2α detection in the blood (compared to relatively healthy donors); in the absence of cardiomyopathy, only similar trends were determined, without significant differences when compared to healthy donors. This evidence concerns the gene EPAS1 and coronary artery disorder.