EPAS1 and coronary artery disorder: Despite the presence of heart failure of comparable severity in patients of both groups (Table 1), in CHD patients without cardiomyopathy, the HIF-1α and HIF-2α content did not differ from the parameters of healthy donors, and in patients with ICMP, there was a HIF-1α deficiency with an elevated HIF-2α level (Figure 1B,C).