At the same time, the comparison of the monocytic immunophenotype endothelial progenitor cells (EPCs) and endothelial desquamated cells (EDCs) levels in the blood allows the determination of the adequacy of the angiogenesis mechanisms in relation to the severity of endothelial damage within coronary vessels, and the hypoxia-induced factors HIF-1 and HIF-2 balance reveal the features of mediator response of cells to hypoxia in ICMP compared to CHD without cardiomyopathy. The gene discussed is HIF1A; the disease is coronary artery disorder.