In order to study the balance of the mediators of angiopoietic endothelial dysfunction in the heart and systemic circulation of CHD patients, suffering (39 men and 5 woman, aged 61.5 [57.5; 65.0] years) and not suffering (33 men and 7 women, aged 64.5 [58.5; 68.0] years, p = 0.192) from ICMP, the concentrations of SDF-1, MCP-1, Ang-2, MMP-9, galectin-3 and growth factors, namely, VEGF-A, VEGF-B and PDGF, were determined in the blood, sampled from the cubital vein and coronary sinus. This evidence concerns the gene ANGPT2 and endothelial dysfunction.