At the same time, the mechanisms of these mediators’ formation in the heart are interconnected, which is confirmed by a positive association between the level of ADMA and endothelin-1 in the coronary blood flow (see Section 3.4), which was determined in a pooled sample of CHD patients (Figure 2C) and in patients with ICMP (Figure 3B). Here, EDN1 is linked to coronary artery disorder.