CXCL1 and colorectal carcinoma: Some clinical investigations have demonstrated that CXCL1 expression is higher in CRC tissue in comparison to a healthy control and is significantly correlated with a larger tumor size, more advanced tumor stage, greater depth of invasion and presence of lymph node metastasis, larger tumor diameter, and higher CEA levels [30,31,32,33,34,35,36,37,38].