When we analyzed the association between concentrations of the tested proteins and the clinicopathological characteristics of the tumor, such as the depth of tumor invasion (T factor) and the presence of lymph nodes (N factor) and distant metastases (M factor), CXCL1 concentrations were the lowest in the T4 subgroup than in the T1 + 2 and T3 patients (Table 3). This evidence concerns the gene CXCL1 and neoplasm.