HMGCR and amyotrophic lateral sclerosis: As shown in Figure 6, three medications were found to have suggested associations with higher ALS development risk: antithrombotic agents (OR = 1.234, 95% CI = 1.042–1.461, p = 0.015), HMG CoA reductase inhibitors (OR = 1.085, 95% CI = 1.025–1.148, p = 0.005), and salicylic acid and derivatives (OR = 1.294, 95% CI = 1.078–1.553, p = 0.006).