We analysed the serum profile of 42 amino acids (AAs) in 76 AD children aged 2-60 months with an IgE-mediated FA (<i>n</i> = 36), with a non-IgE-mediated FA (<i>n</i> = 15) and without an FA (<i>n</i> = 25) using high-performance liquid chromatography coupled with mass spectrometry (LC-MS/MS) and an aTRAQ kit. Here, IGHE is linked to Alzheimer disease.