PYGM and systemic inflammatory response syndrome: Another example of the potential diagnostic role of EVs in the context of SIC is a recent study published by Hegyesi H et al. This study used an LPS-induced systemic inflammatory response syndrome (SIRS) mouse model and demonstrated an increase in CM-derived small and medium EVs containing troponin I and muscle-associated glycogen phosphorylase in the blood [70] (Table 1).