NOS3 and liver dysplastic nodule: Vascular endothelial growth factor (VEGF) was proven to be chemotactic for macrophages, NO was found to negatively regulate VEGF-induced macrophage migration by inhibiting Flt-1 expression, and endothelial nitric oxide synthase (eNOS) knockout mice have been well known to be able to develop advanced glomerular lesions resembling human DN [38].