miR-93-5p expression was markedly upregulated in lipopolysaccharide (LPS)-induced podocytes, one of the DN models in vitro, and inhibition of miR-93-5p or silencing of TLR4, which was a downstream target of miR-93-5p, reversed the reno-protective effects of miR-93-5p-containing exosomes produced by M2 macrophage on LPS-induced podocyte injury [53]. Here, TLR4 is linked to liver dysplastic nodule.