The results of the study conducted by Burillo-Sanz et al. [49], assessing functional polymorphism in genes associated with autoinflammatory diseases (CECR1, MEFV, MVK, NLRP3, NOD2, and PSTPIP1), suggest that a substantial fraction of patients with BD have rare variants of these genes, with a suspected link of MEFV with BD modulated by HLA molecules. This evidence concerns the gene MEFV and Behcet disease.